black, bleak, cheerless, chill, Cimmerian, cloudy, cold, comfortless, dark, darkening, depressing, depressive, desolate, dim, disconsolate, dismal, drear, dreary, dreich [chiefly Scottish], elegiac (also elegiacal), forlorn, funereal, gloomy, glum, godforsaken, gray (also grey), lonely, lonesome, lugubrious, miserable, morbid, morose, murky, plutonian, saturnine, sepulchral, somber (or sombre), sullen, sunless, tenebrific, tenebrous, wretched

discouraging, disheartening, hopeless, unfavorable, unpromising, unpropitious

ill-fated, ill-starred, star-crossed, troubled, unfortunate, unlucky

evil, malign, malignant

hostile, inimical, unfriendly

contagious, deadly, infectious, infective, pestiferous, pestilent, pestilential, poisonous, venomous

insidious, menacing, ominous, sinister, threatening

hazardous, imperiling (or imperilling), jeopardizing, parlous, perilous, risky, unsafe, unsound

nasty, noisome, unhealthful, unhealthy, unwholesome

destructive, fatal, killer, lethal, malignant, ruinous