agonizing, excruciating, torturous

damaging, deleterious, detrimental, harmful, hurtful, injurious, noxious, pernicious

raw, tender

bleeding, burning, chafing, cramping, festering

itching, nagging, pinching, pricking, prickling, smarting, stinging

inflamed (also enflamed), swollen

grievous, severe, threatening, wounding