trimetrexate
noun
tri·me·trex·ate
| \ ˌtrī-mi-ˈtrek-ˌsāt
\
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Medical Definition of trimetrexate
: a toxic drug structurally related to methotrexate that is administered in the form of its glucuronate C19H23N5O3·C6H10O7 with concomitant administration of leucovorin to reduce toxicity and is used especially in the treatment of Pneumocystis carinii pneumonia and certain carcinomas