downstream

adverb or adjective
down·​stream | \ ˈdau̇n-ˈstrēm How to pronounce downstream (audio) \

Definition of downstream

1 : in the direction of or nearer to the mouth of a stream floating downstream located two miles downstream
2 : in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture improving profits downstream downstream products
3 biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.— Marcia Barinaga

Examples of downstream in a Sentence

Recent Examples on the Web

Even as the storm continues north, some have been concerned that water could come back downstream along the Mississippi from flooding inland. Michael Nedelman, CNN, "A sunken barge might have saved these Louisiana towns from major flooding," 15 July 2019 His body was recovered two days later about 10 miles downstream, WTVM reported. Leada Gore | Lgore@al.com, al.com, "6-year old Alabama drowning victim gets Paw Patrol final resting place," 10 July 2019 That effect would cascade downstream, putting pressure on other dams and flooding the low-lying areas those dams were designed in part to protect. John D'anna, azcentral, "For a while in 1983, sheets of plywood were all that kept the mighty Glen Canyon Dam from overflowing," 18 July 2019 Under worst-case scenario modeling, some recreational areas downstream from McQueeney could be quickly submerged under five feet of water, though homes and bridges would not be in jeopardy. Josh Baugh, ExpressNews.com, "With dams at risk of failing, GBRA looks to drain four lakes on Guadalupe River," 17 July 2019 Maybe one billion people live downstream from the Himalaya, along big rivers in India and Nepal and Bangladesh. National Geographic, "This polar explorer is skiing the Arctic to show just how much ice is really gone," 3 July 2019 An adult woman who was hanging on to a tree branch downstream was rescued by using a throwbag, according to TSCFD, while the two children were found further downstream. Lucas Aulbach, The Courier-Journal, "Authorities search for man who went missing after attempting to cross flooded bridge," 17 June 2019 Damage extends downstream into Arkansas following heavy spring rains. Washington Post, "Mike Pence pledges to rebuild after Oklahoma flood damage," 5 June 2019 Hernandez went to help Santay but was also pulled into the powerful river and traveled downstream. Robin Goist, cleveland.com, "Search continues for missing swimmer in Cuyahoga River in Akron," 3 June 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'downstream.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of downstream

1591, in the meaning defined at sense 1

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More Definitions for downstream

downstream

adverb or adjective

Financial Definition of downstream

What It Is

Downstream refers to the benefits (or costs) that will ultimately result from decisions made today.

How It Works

In finance, a series of investments might be made with the anticipation that at a point in time in the future these efforts will yield a series of returns.  These returns occur after the initial investments.  As a result, they are referred to as downstream benefits.  Similarly, investments can have downstream "costs" as well.   The expectation is that the downstream benefits will outweigh the downstream costs.

At the same time, because the future is hard to predict, downstream effects are often unanticipated, setting off unintended costs and consequences.

Why It Matters

It is important to consider the "downstream" effects of an investment decision since it will impact ones future economic performance.

Source: Investing Answers

downstream

adverb

English Language Learners Definition of downstream

: in the direction in which a stream, river, etc., flows

downstream

adverb
down·​stream | \ ˈdau̇n-ˈstrēm How to pronounce downstream (audio) \

Kids Definition of downstream

: in the direction a stream is flowing paddling downstream

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downstream

adverb or adjective
down·​stream | \ ˌdau̇n-ˈstrēm How to pronounce downstream (audio) \

Medical Definition of downstream

1 : in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide a nucleotide sequence located downstream from the regulatory gene effects on the expression of downstream genes — compare upstream sense 1
2 : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.— Marcia Barinaga, Science, 7 Nov. 1997 The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.— Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine, 24 Feb. 2005

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