: any of several American pit vipers (genera Crotalus and Sistrurus) that have horny interlocking joints at the end of the tail which make a sharp rattling sound when shaken
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: any of the American pit vipers that have a series of horny interlocking joints at the end of the tail which make a sharp rattling sound when vibrated and that comprise the genera Sistrurus and Crotalus — see diamondback rattlesnake, tiger rattlesnake, timber rattlesnake