Santa Cruz
geographical name
\ ˈkrüz
\
\
Definition of Santa Cruz
1
island in the Pacific off southwestern California in the northwestern Channel Islands
2
city in western California south of San Jose on Monterey Bay population 59,946
3
— see saint croix sense 3
4
river 250 miles (402 kilometers) long in southern Argentina flowing east into the Atlantic Ocean
5
city in eastern Bolivia population 1,448,000